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For quantification of nuclear 8-oxodGuo, images of the dermal/epidermal junctional area of the skin taken at 100 magnification were processed using a protocol created to separate the nuclei based on the DAPI-labelling signal

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Key Observations from Phase 2 Data Dose escalation reduced adverse events: Groups that used gradual dose titration reported fewer GI events than those starting at the target dose directly No deaths were attributed to the study drug Serious adverse events were reported at low rates across all groups, with no clear dose-dependent pattern for serious events The placebo group also reported substantial adverse events (72.1%), which is typical for trials of this size and duration TRIUMPH Phase 3 Adverse Event Profiles The TRIUMPH program consists of eight Phase 3 trials evaluating retatrutide across multiple indications including obesity, type 2 diabetes, and metabolic-associated steatotic liver disease (MASLD)

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An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH